Can superoxide dismutase alter myocardial infarct size?

Can superoxide dismutase alter myocardial infarct size?

R eperfusion therapy for acute myocardial infarction reduces myocardial dysfunction and mortality. However, reperfusion can also injure myocardium,' and adjunctive agents have been sought to limit reperfusion injury. After laboratory reports of successful reduction in infarct size by superoxide dismutase (SOD) after ischemia and reperfusion,2-7 SOD became the first of these agents to be used in...

Superoxide Dismutase Therapy in Experimental Myocardial Infarction Polyethylene Glycol-Superoxide Dismutase Plus Catalase Does Not Limit Myocardial Infarct Size in Dogs

We previously found that superoxide dismutase (SOD) did not limit myocardial infarct size after 40 or 90 minutes of ischemia and 4 days of reperfusion in dogs. Because some other studies have shown limitation of infarct size after shorter periods of reperfusion, we postulated that our negative results might be due to late reperfusion injury mediated by superoxide anions produced after excretion...

MYOCARDIAL INFARCTION Reduction in experimental infarct size by recombinant human superoxide dismutase : insights into the pathophysiology of reperfusion injury

To determine the importance of reperfusion injury and the ability of the free-radical scavenger recombinant human superoxide dismutase (h-SOD) to prevent it, open-chest dogs underwent 90 min of proximal circumflex coronary artery occlusion, and only at the moment of reperfusion received either h-SOD (400,000 IU bolus into the left atrium followed by a 300,000 IU iv infusion over 1 hr) or saline...

Superoxide dismutase Superoxide dismutase

Relationship Between Myocardial Infarct Size

We compared myocardial infarct size produced by permanent occlusion of the middle left anterior descending (LAD) or circumflex (LCx) coronary artery in the anesthetized dog. The dogs were killed 3-10 days later, and the occluded coronary bed was visualized by postmortem arteriography. The outlines of the infarct and occluded bed were marked on tracings of weighed left ventricular (LV) rings and...